Epidemiology of intracranial aneurysms in Pakistani population

Genetic Polymorphism of CYP2C19 in Pakistani Population

CYP2C19 polymorphism is associated with pretreatment drug response prediction, metabolism, and disposition. Pakistan consists of a population comprising of various ethnic groups residing in different regions of the country each claiming diverse ethnic origins. The identification of CYP450 genotypic composition of these populations is therefore necessary to avoid adverse drug reactions in these ...

Prevalence of Gynaecomastia in Male Pakistani Population

Genetic Polymorphism of CYP2C19 in Pakistani Population

CYP2C19 polymorphism is associated with pretreatment drug response prediction, metabolism, and disposition. Pakistan consists of a population comprising of various ethnic groups residing in different regions of the country each claiming diverse ethnic origins. The identification of CYP450 genotypic composition of these populations is therefore necessary to avoid adverse drug reactions in these ...

Natural history, epidemiology and screening of unruptured intracranial aneurysms.

The prevalence of intracranial aneurysms is 2.3% (95% CI, 1.7-3.1%); most of these aneurysms are small and located in the anterior circulation. Risk factors are age, female gender, smoking, hypertension, excessive use of alcohol, having one or more affected relatives with SAH and autosomal dominant polycystic kidney disease. Most studies on risk of rupture have methodological weaknesses; an imp...

Genetic Determinants of Unruptured Intracranial Aneurysms in the General Population.

BACKGROUND AND PURPOSE Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) for intracranial aneurysms in clinical samples. In addition, SNPs have been discovered for blood pressure, one of the strongest risk factors for intracranial aneurysms. We studied the role of these genetic variants on occurrence and size of unruptured intracranial aneurysms, discovered ...